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10.3390/cells13141175 54 KhanS.HussainA.AttarF.BloukhS

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Notably, although gcs-1 induction is impaired in CSN-deficient animals (Figures 3A,B, 2B upper panel), the high basal gcs-1 expression and increased expression of other phase 2 detoxification genes, e.g., gst-7 (Figure 2B lower panel, see Additional file 2: Figure S5), is sufficient to confer increased oxidative stress resistance (Figures 2C and 3C) [17]